SERIES : PROUD MOMENTS -2
With ordinary talent and extraordinary perseverance, all things are attainable
Meet Akash Manoj, a class 10 student and son of a Tamil Nadu based businessman and a homemaker mother. When teenagers around him were busy reading fantasy fiction, Akash Manoj was busy reading medical literature that would help him to develop a device to detect ‘silent heart attacks’.
HE earned international acclaim for developing a technique for self diagnosis of a silent heart attack — a small silicon patch stuck to your wrist or back of your ear which can be used to monitor whether there has been a heart attack. His technique is currently undergoing clinical trials. 15-yr-old boy behind device to predict silent heart attack describes ‘wonderful’ at Rashtrapati Bhavan upon receiving Grassroot award at 9th National Biennial Competition, which ran from April 1, 2013 to March 31, 2015 .
Details of Innovation:
On July 3rd 2015, Mr Akash Manoj 's grandfather collapsed due to heart attack and this served as an impetus for Akash to find a solution to this problem. Silent heart attacks, which appear with little to no symptoms, are alarmingly common and extremely deadly. There is currently no way to detect a silent heart attack
because it quite impossible to detect the FABP3, an optimal biomarker for cardiac ischemia. Hence, it seems that the only way to enable biomarker-based diagnosis for silent heart attacks is to allow at-risk patients themselves to frequently
analyse their blood for these proteins and subsequently, the patient will be alerted of a silent heart attack. The purpose of the innovator was to investigate a technique that can potentially be coupled up with transcutaneous UV-protein quantification to non-invasively measure the amount of FABP3 in a patient's blood and alert him or her of a silent heart attack. While conducting the experiment, Akash found that it is possible to transcutaneously detect FABP3, a biomarker of heart
attack-associated cardiac ischemia, in the blood through an two-step process. FABP3 is one of the smallest proteins that can be present in blood, and is charged negatively (so it attracts to positive charges). These properties can be used to identify it in blood without puncturing the skin. His results showed that:
When a small enough positive electric potential is applied t a thin and translucent area of skin (i.e. the external ear), FABP3 is the only protein that attracts to the positive charge because it is the smallest (and therefore the most sensitive) protein that can be present in the blood. As a result, the FABP3 accumulates
on the capillary walls in this positively charged skin, while all other proteins pass by unaffected.
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.......................................................
Innovation Scholars In-Residence Programme
Non-invasive Self Diagnosis of Silent heart attack
Prevention is better than cure
The results showed that, when a 173 mV potential of positive electricity was applied to the model, at this point the accumulation of FABP3 exceeded that of albumin on the silicone. Slightly below 173 mV, albumin accumulation ceased altogether, and only FABP3 accumulated at voltages lower than this. This means that it is true that, if a positive potential of a low enough voltage is applied to thin human skin, only FABP3 will accumulate on the dermal capillaries and become detectable by UV quantification. This consisted of a method that allows daily self-testing would have to be noninvasive, safe, and easy to use. Ultimately, it would have to involve a transcutaneous blood analysis, which examines the contents of one's blood without penetrating the skin. In searching for ways to tackle this challenging prospect, Akash examined the various distinguishing characteristics of
blood proteins that would all of them to be identify tscutaneously and found out that proteins have distinctive masses and electric charges in blood. To check this, he used a model to test whether different magnitudes of charged electricity, when applied to a thin area of skin, would isolate FABP3 from the other blood proteins and attract FABP3 to the capillary walls and the results to this examination showed
that this is true.......When enough of the FABP3 protein has accumulated on the charged capillaries, it can be measured through UV light quantification, in which UV light is passed through the thin skin in which the FABP3 accumulated, and a sensor detects the amount of protein there based on the how much of the light was absorbed. UV protein quantification is already commonly used ex vivo. He used a model to simplistically resemble FABP3-positive blood in dermal capillaries with several positive
electric charges applied. The model consisted of a silicone membrane (representing the dermal capillaries), and a drop of albumin/FABP3 solution to simulate blood, on top of it. An electrode patch applied positively charged electric potentials of several different magnitudes to the silicone and the accumulation of the FABP3 on the silicone was compared to that of albumin for each potential. The next follows the UV quantification process to determine...................................................
Courtesy : Rashtrapati Bhawan releases
Meet Akash Manoj, a class 10 student and son of a Tamil Nadu based businessman and a homemaker mother. When teenagers around him were busy reading fantasy fiction, Akash Manoj was busy reading medical literature that would help him to develop a device to detect ‘silent heart attacks’.
HE earned international acclaim for developing a technique for self diagnosis of a silent heart attack — a small silicon patch stuck to your wrist or back of your ear which can be used to monitor whether there has been a heart attack. His technique is currently undergoing clinical trials. 15-yr-old boy behind device to predict silent heart attack describes ‘wonderful’ at Rashtrapati Bhavan upon receiving Grassroot award at 9th National Biennial Competition, which ran from April 1, 2013 to March 31, 2015 .
Details of Innovation:
On July 3rd 2015, Mr Akash Manoj 's grandfather collapsed due to heart attack and this served as an impetus for Akash to find a solution to this problem. Silent heart attacks, which appear with little to no symptoms, are alarmingly common and extremely deadly. There is currently no way to detect a silent heart attack
because it quite impossible to detect the FABP3, an optimal biomarker for cardiac ischemia. Hence, it seems that the only way to enable biomarker-based diagnosis for silent heart attacks is to allow at-risk patients themselves to frequently
analyse their blood for these proteins and subsequently, the patient will be alerted of a silent heart attack. The purpose of the innovator was to investigate a technique that can potentially be coupled up with transcutaneous UV-protein quantification to non-invasively measure the amount of FABP3 in a patient's blood and alert him or her of a silent heart attack. While conducting the experiment, Akash found that it is possible to transcutaneously detect FABP3, a biomarker of heart
attack-associated cardiac ischemia, in the blood through an two-step process. FABP3 is one of the smallest proteins that can be present in blood, and is charged negatively (so it attracts to positive charges). These properties can be used to identify it in blood without puncturing the skin. His results showed that:
When a small enough positive electric potential is applied t a thin and translucent area of skin (i.e. the external ear), FABP3 is the only protein that attracts to the positive charge because it is the smallest (and therefore the most sensitive) protein that can be present in the blood. As a result, the FABP3 accumulates
on the capillary walls in this positively charged skin, while all other proteins pass by unaffected.
................................
.......................................................
Innovation Scholars In-Residence Programme
Non-invasive Self Diagnosis of Silent heart attack
Prevention is better than cure
The results showed that, when a 173 mV potential of positive electricity was applied to the model, at this point the accumulation of FABP3 exceeded that of albumin on the silicone. Slightly below 173 mV, albumin accumulation ceased altogether, and only FABP3 accumulated at voltages lower than this. This means that it is true that, if a positive potential of a low enough voltage is applied to thin human skin, only FABP3 will accumulate on the dermal capillaries and become detectable by UV quantification. This consisted of a method that allows daily self-testing would have to be noninvasive, safe, and easy to use. Ultimately, it would have to involve a transcutaneous blood analysis, which examines the contents of one's blood without penetrating the skin. In searching for ways to tackle this challenging prospect, Akash examined the various distinguishing characteristics of
blood proteins that would all of them to be identify tscutaneously and found out that proteins have distinctive masses and electric charges in blood. To check this, he used a model to test whether different magnitudes of charged electricity, when applied to a thin area of skin, would isolate FABP3 from the other blood proteins and attract FABP3 to the capillary walls and the results to this examination showed
that this is true.......When enough of the FABP3 protein has accumulated on the charged capillaries, it can be measured through UV light quantification, in which UV light is passed through the thin skin in which the FABP3 accumulated, and a sensor detects the amount of protein there based on the how much of the light was absorbed. UV protein quantification is already commonly used ex vivo. He used a model to simplistically resemble FABP3-positive blood in dermal capillaries with several positive
electric charges applied. The model consisted of a silicone membrane (representing the dermal capillaries), and a drop of albumin/FABP3 solution to simulate blood, on top of it. An electrode patch applied positively charged electric potentials of several different magnitudes to the silicone and the accumulation of the FABP3 on the silicone was compared to that of albumin for each potential. The next follows the UV quantification process to determine...................................................
Courtesy : Rashtrapati Bhawan releases
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